Hernando A. del Portillo

Hernando A. del Portillo

Institut de Salut Global Barcelona

Life & Medical Sciences

I studied at the University of Georgia where I received my PhD in 1985 followed by two WHO-postdoctoral trainings at the New York University Medical Centre and the Institut Pasteur where I specialized in molecular biology of malaria.  Next, I consolidated an interdisciplinary malaria research group at the University of Sao Paulo, Brazil.  In 1990, I did a sabattical year at the Center for Molecular Biology (ZMBH), University of Heidelberg. In 2007, I became an ICREA Research Professor and joined the Barcelona Institute for Global Health, and in 2016 co-joined the Institut d’Investigació Germans Trias i Pujol. Cornerstones of this research activity are the discovery of the largest multigene virulent family of human malaria parasites and the discovery that reticulocyte-derived exosomes from infections act as intercellular communicators and can be used as vaccines and biomarkers.

Research interests

My main research area is the biology of Plasmodium vivax, a neglected human malaria parasite responsible for millions of yearly clinical cases. We are presently looking for mechanistic insights of the role of reticulocyte-derived exosomes, nanovesicles of endocytic origin, in signalling the spleen and the bone marrow to unveil molecular basis of anaemia and splenomegaly.  To pursue bone marrow and spleen studies,  we are implementing the usage of humanized mouse models and organs-on-chip. To use this information in novel control strategies, we are exploring the use of reticulocyte-derived exosomes as a novel vaccine against P. vivax as well as novel biomarkers of liver hypnozite asymptomatic infections. To this end, we are immortalizing cell lines and constructig POC microfluidic devices. Last, to rapidly move this field to translation, we are pursuing the development of exosome-based vaccines against infectious diseases of veterinary importance.

Selected publications

- Haruka Toda, Miriam Diaz-Varela, Joan Segui-Barber, Wanlapa Roobsoong, Barbara Baro, Susana Garcia-Silva, Alicia Galiano, Melisa Gualdrón-López, Anne CG Almeida, Marcelo AM Brito, Gisely Cardoso de Melo, Iris Aparici-Herraiz, Carlos Castro-Cavadía, Wuelton Marcelo Monteiro, Eva Borras, Eduard Sabido, Igor C. Almeida, Jakub Chojnacki, Javier Martinez-Picado, Maria Calvo, Pilar Armengol, Jaime Carmona-Fonseca, Maria Fernanda Yasnot, Ricardo Lauzurica, Antonio Marcilla, Hector Peinado, Mary R. Galinski, Marcus VG Lacerda, Jetsumon Sattabongkot, Carmen Fernandez-Becerra* and Hernando A del Portillo* (*equal correspondence) 2020. 'Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence'. Nat Commun. 11(1):2761.

- Monteiro, Wuelton; Brito-Sousa, Jose Diego; Elizalde-Torrent, Aleix; Botto-Menezes, Camila; Melo, Gisely Cardoso; Fernandez-Becerra, Carmen; Lacerda, Marcus; del Portillo, Hernando A. 2020, 'Cryptic Plasmodium chronic infections: was Maurizio Ascoli right?', Malaria Journal, 19, 1, 440.

- Carmen Fernandez-Becerra*, Maria Bernabeu, Angélica Castellanos, Bruna R. Correa, Thomas Obadia, Miriam Ramirez, Edmilson Rui, Franziska Hentzschel, Maria López-Montañés, Alberto Ayllon-Hermida, Lorena Martin-Jaular, Aleix Elizalde-Torrent, Peter Siba, Ricardo Vencio, Myriam Arevalo-Herrera, Sócrates Herrera, Pedro L. Alonso, Ivo Mueller and Hernando A. del Portillo* 2020. (*equal correspondence). Plasmodium vivaxspleen-dependent genes encode antigens associated with cytoadhesion and clinical protection. Proc Natl Acad Sci U S A. 217(23):13056-13065. 

Selected research activities

Invited talks: Virtual meeting of the Israel Society of Parasitology, Protozoology and Tropical Diseases (ISPPTD) 2020 and WEBEVTalk series.

Ph.D. Thesis: Haruka Toda. Physiological role of circulating extracellular vesicles in Plasmodium vivax infections. ISGlobal