Hernando A. del Portillo Obando

Hernando A. del Portillo Obando

Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol & Institut de Salut Global Barcelona

Life & Medical Sciences

I studied at the University of Georgia where I received my PhD in 1985 followed by two WHO-postdoctoral trainings at the New York University Medical Centre and the Institut Pasteur where I specialized in molecular biology of malaria. Next, I consolidated an interdisciplinary malaria research group at the University of Sao Paulo, Brazil. In 1990, I did a sabattical year at the Center for Molecular Biology (ZMBH), University of Heidelberg. In 2007, I became an ICREA Research Professor and joined the Barcelona Institute for Global Health, and in 2016 co-joined the Institut d’Investigació Germans Trias i Pujol. Cornerstones of this research activity are the discovery of the largest multigene virulent family of human malaria parasites and the discovery that reticulocyte-derived exosomes from infections act as intercellular communicators and can be used as vaccines and biomarkers.

Research interests

My main research area is the biology of Plasmodium vivax, a neglected human malaria parasite responsible for millions of yearly clinical cases. We are presently looking for mechanistic insights of the role of reticulocyte-derived exosomes, nanovesicles of endocytic origin, in signalling the spleen and the bone marrow to estabish cryptic erythrocytic infections. To pursue bone marrow and spleen studies, we are implementing the usage of humanized mouse models and organs-on-chip. To use this information in novel control strategies, we are exploring the use of reticulocyte-derived exosomes as a novel vaccine against P. vivax as well as novel biomarkers of asymptomatic infections. Last, to rapidly move this field to translation, we are pursuing the development of exosome-based vaccines against infectious diseases of veterinary importance.

Selected publications

– Fernandez-Becerra C, Xander P, et al. 2023, ‘Guidelines for the purification and characterization of extracellular vesicles of parasites’, Journal of Extracellular biology, 2, 10.

Selected research activities

  • MOVE Award to recognize the resercher who made a great contribution to push forward the MOVE ProjectFirst MOVE symposium to foster Mobility for Vesicles research in Europe held in Malaga
  • Invited talk – Joint International Tropical Medicine Meeting (JITMM2023) at Eastin Grand Hotel Phayathai, Bangkok Thailand
  • Invited talk – Extracellular Vesicles: friends and foes II Conference at the Weizmann Institute of Science, Rehovot, Israel.