Roger Gomis

Roger Gomis

Institut de Recerca Biomèdica de Barcelona

Life & Medical Sciences

Dr. Roger Gomis is an ICREA Research Professor and a member of the Oncology Program at the Institute for Research in Biomedicine, Barcelona. He received his PhD in biochemistry from the University of Barcelona in 2002, and was a postdoctoral fellow at Memorial Sloan-Kettering Cancer Center in Prof. Joan Massagué's laboratory. In 2007, he assumed his current position. Since 2018 he is an associate professor at the University of Barcelona. Dr. Roger Gomis is interested in how growth factors, signaling pathways, and gene expression programs control normal cell behavior and cancer cell metastasis. Driven by the problem of metastasis, which is the cause of 90% of cancer deaths, his laboratory is pursuing the molecular and genetic mechanisms of metastasis. In particular, identifying  genes that enable cancer to metastasize clinically relevant sites. In 2012 Roger founded Inbiomotion as an ICREA and IRB Barcelona spin-off company from his research. 

Research interests

Intricate signalling networks control cell division, differentiation, movement, organization and death. Cancer cells disobey these signals during tumour progression and metastasis, which is the final step in 90% of all fatal solid tumours. Metastasis is therefore a grave public health problem and consequently a field of considerable pharmaceutical interest. A major research focus of our group is to identify and understand the genes and functions that allow tumor cells to achieve metastatic colonization of vital organs. As we understand more about the biology of BC cells, we can begin to address how best to treat this form of disease. Key to determining whether dormant solitary cells or micrometastases represent valid targets is knowledge of the underlying biology of dormancy and the probability of cells progressing to active metastatic growth. This progression is poorly understood in preclinical models and even less so clinically and has become of our interest.

Selected publications

- Urosevic J, Blasco MT, Llorente A, Bellmunt A, Berenguer-Llergo A, Guiu M, Cañellas A, Fernandez E, Burkov I, Clapés M, Cartanà M, Figueras-Puig C, Batlle E, Nebreda AR & Gomis RR 2020. 'ERK1/2 signaling induces upregulation of ANGPT2 and CXCR4 to mediate liver metastasis in colon cancer.' Cancer Res. 80, 21, 4668 - 4680.

- Blasco MT & Gomis RR. 2020. 'PD-L1 controls cancer pyroptosis'. Nat Cell Biol. 2020 Oct;22(10):1157-1159.

- Pascual R, Martín J, Salvador F, Reina O, Chanes V, Millanes-Romero A, Suñer C, Fernández-Miranda G, Bartomeu A, Huang YS, Gomis RR, Méndez R. 2020.'The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer'. Science Advances, 2020 May 15;6(20):eaax3868. doi: 10.1126/sciadv.aax3868. eCollection 2020 May.

- Hermanova I, Zúñiga-García P, Caro-Maldonado A, Fernandez-Ruiz S, Salvador F, Martín-Martín N, Zabala-Letona A, Nuñez-Olle M, Torrano V, Camacho L, Lizcano JM, Talamillo A, Carreira S, Gurel B, Cortazar AR, Guiu M, López JI, Martinez-Romero A, Astobiza I, Valcarcel-Jimenez L, Lorente M, Arruabarrena-Aristorena A, Velasco G, Gomez-Muñoz A, Suárez-Cabrera C, Lodewijk I, Flores JM, Sutherland JD, Barrio R, de Bono JS, Paramio JM, Trka J, Graupera M, Gomis RR, Carracedo A. 2020. 'Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer'. J Exp Med. 2020 Jun 1;217(6):e20191787. doi: 10.1084/jem.20191787.

Selected research activities

Chair - Cancer Study SectionSpanish Government Agency for the Evaluation of Research