Pau Gorostiza

Pau Gorostiza

Institut de Bioenginyeria de Catalunya

Life & Medical Sciences

Pau Gorostiza graduated in physics at the University of Barcelona (UB), where he obtained his PhD (European Doctorate) in the field of semiconductor electrochemistry. He worked at the UB microscopy facility in AFM and STM of biological samples, and in nanotechnology for materials science. He visited the CNRS - Université Pierre et Marie Curie (France), and the University of California at Berkeley (USA). He is currently ICREA Research Professor at the Institute for Bioengineering of Catalonia, where he develops photoswitchable ligands of neuronal proteins and studies charge transport in redox proteins and photosynthetic complexes using EC-STM/AFM. He obtained a Human Frontier Science Program (HFSP) Career Development Award and two European Research Council (ERC) grants. He published more than 100 articles (3500 citations, h-index 31) and holds 7 patents (5 licensed). He has supervised 8 postdoctoral fellows and 9 PhDs.

Research interests

Research in the group is focused on developing nanoscale tools to study biological systems. These tools include instrumentation based on proximity probes, like Electrochemical Tunneling Microscopy and Spectroscopy, that we are applying to study metal oxides and redox proteins. Another set of nanotools that we are developing is based on molecular actuators that can be switched with light, like azobenzene, which can be chemically attached to biomolecules in order to optically control their activity.

Selected publications

– López-Martinez M, López-Ortiz M, Antinori ME, Wientjes E, Nin-Hill A, Rovira C, Croce R, Díez-Pérez I & Gorostiza P 2019, ‘Electrochemically Gated Long-Distance Charge Transport in Photosystem I‘, Angewandte Chemie-international Edition, 58, 38, 13280-13284

– Riefolo F, Matera C, Garrido-Charles A, Gomila AMJ, Sortino R, Agnetta L, Claro E, Masgrau R, Holzgrabe U, Batlle M, Decker M, Guasch E & Gorostiza P 2019, ‘Optical Control of Cardiac Function with a Photoswitchable Muscarinic Agonist‘, Journal Of The American Chemical Society, 141, 18, 7628 – 7636.

– Cabré G, Garrido-Charles A, Moreno M, Bosch M, Porta-de-la-Riva M, Krieg M, Gascon-Moya M, Camarero N, Gelabert R, Lluch JM, Busqué F, Hernando J, Gorostiza P & Alibés R 2019, ‘Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation‘, Nature Communications, 10, 907.

– Pittolo S, Lee H, Lladó A, Tosi S, Bosch M, Bardia L, Gómez-Santacana X, Llebaria A, Soriano E, Colombelli J, Poskanzer KE, Perea G & Gorostiza P 2019, ‘Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology‘, Proceedings Of The National Academy Of Sciences Of The United States Of America, 116, 27, 13680 – 13689.

– Cabré G, Garrido-Charles A, González-Lafont A, Moormann W, Langbehn D, Egea D, Lluch JM, Herges R, Alibés R, Busqué F, Gorostiza P & Hernando J 2019, ‘Synthetic Photoswitchable Neurotransmitters Based on Bridged Azobenzenes‘, Organic Letters, 21, 10, 3780 – 3784.

– Maleeva G, Wutz D, Rustler K, Nin-Hill A, Alfonso-Prieto M, Petukhova E, Bautista-Barrufet A, Gomila-Juaneda A, Scholze P, Peiretti F, Rovira C, König B, Gorostiza P & Bregestovski P 2019, ‘A photoswitchable GABA receptor channel blocker‘, British Journal Of Pharmacology, 176, 15, 2661 – 2677.