I am a vascular biologist with expertise in signalling. I have been trained in several institutions, including the University of Barcelona, the Hospital Clinic de Barcelona, the Ludwig Institute for Cancer Research, and the Bart’s Cancer Institute in London. In 2009 I established my lab as an independent investigator at d’Investigació Biomèdica de Bellvitge (IDIBELL) funded by the Ramon y Cajal program. In February 2021, I joined the Josep Carreras Leukaemia Research Institute as Group leader with an interest to study the ties between the hematopoietic and endothelial cell linages. From June 2023 to June 2025, I served as President of the European Vascular Biology Organization (EVBO). In January 2023, I was appointed ICREA Research Professor.
Research interests
As a vascular biologist, I study the molecular and cellular mechanisms that govern vascular growth in both physiological and pathological contexts. Within this expansive field, I have chosen to concentrate my efforts on three primary research lines: the first explores the intricate relationship between adipose ECs and obesity, investigating how these cells influence WAT expansion and health; the second research line delves into the fascinating field of vascular malformations, seeking to elucidate the underlying mechanisms that lead to abnormal vascular development and their subsequent impact on health; the third research line is focused on understanding how endothelial cells behave during tumour onset and in metastatic settings. By probing these areas, my work aims to elucidate critical aspects of vascular biology, potentially paving the way for novel insights and therapeutic interventions in cardiovascular and metabolic diseases.
Selected publications
- Martin-Martin, N et al. 2025, 'Transcriptional analysis of metastatic hormone-naïve prostate cancer primary tumor biopsies reveals a relevant role for SOX11 in prostate cancer cell dissemination', Genome biology, 26 - 1 -154.
- Ercilla A, Crespo JR, Garcia-Longarte S, Fidalgo M, del Palacio S, Martin-Martin N, Carlevaris O, Astobiza I, Fernández-Ruiz S, Guiu M, Bárcena L, Mendizabal I, Aransay AM, Graupera M, Gomis RR & Carracedo A 2025, 'A bioinformatics screen identifies TCF19 as an aggressiveness-sustaining gene in prostate cancer', Molecular oncology. vol.19, issue 12, 3634-3650.
- Castillo, SD et al. 2025, 'Somatic Uniparental Disomy of PTEN in Endothelial Cells Causes Vascular Malformations in Patients with PTEN Hamartoma Tumor Syndrome', Cancer discovery, 15 - 7 - 1350 - 1362.