Manuel Irimia

Manuel Irimia

Centre de Regulació Genòmica

Life & Medical Sciences

Manuel Irimia obtained his PhD in 2010 at University of Barcelona investigating the origin of vertebrates at a genomic level. After two postdocs at Stanford University and University of Toronto, he joined the Centre for Genomic Regulation (CRG) in June 2014. He has been elected EMBO Young Investigator (2018) and obtained ERC Starting (2014) and Consolidator (2020) Grants.

Research interests

Manuel Irimia's research is centered on two major questions: How does a single genome sequence encode the information to build the enormous complexity of cell types and structures of an adult organism? How are changes in this sequence translated into morphological novelties during evolution? To address these questions, his lab combines computational and experimental approaches using in vitro and in vivo systems (zebrafish, mouse and fruitfly) to investigate the roles of transcriptomic diversification and specialization in embryonic development and evolution.

Selected publications

- Almudi, Isabel; Vizueta, Joel; Wyatt, Christopher D. R.; de Mendoza, Alex; Marletaz, Ferdinand; Firbas, Panos N.; Feuda, Roberto; Masiero, Giulio; Medina, Patricia; Alcaina-Caro, Ana; Cruz, Fernando; Gomez-Garrido, Jessica; Gut, Marta; Alioto, Tyler S.; Vargas-Chavez, Carlos; Davie, Kristofer; Misof, Bernhard; Gonzalez, Josefa; Aerts, Stein; Lister, Ryan; Paps, Jordi; Rozas, Julio; Sanchez-Gracia, Alejandro; Irimia, Manuel; Maeso, Ignacio; Casares, Fernando 2020, 'Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings', Nature Communications, 11, 1.

- Bogdanovic, Ozren; Irimia, Manuel 2020, 'Jose Luis Gomez-Skarmeta (1966-2020) obituary', Nature Genetics, vol 52, 1267-1268.

- Martin-Duran, Jose M.; Vellutini, Bruno C.; Marletaz, Ferdinand; Cetrangolo, Viviana; Cvetesic, Nevena; Thiel, Daniel; Henriet, Simon; Grau-Bove, Xavier; Carrillo-Baltodano, Allan M.; Gu, Wenjia; Kerbl, Alexandra; Marquez, Yamile; Bekkouche, Nicolas; Chourrout, Daniel; Gomez-Skarmeta, Jose Luis; Irimia, Manuel; Lenhard, Boris; Worsaae, Katrine; Hejnol, Andreas 2020, 'Conservative route to genome compaction in a miniature annelid', Nature Ecology & Evolution, .

- Touceda-Suarez, Maria; Kita, Elizabeth M.; Acemel, Rafael D.; Firbas, Panos N.; Magri, Marta S.; Naranjo, Silvia; Tena, Juan J.; Gomez-Skarmeta, Jose Luis; Maeso, Ignacio; Irimia, Manuel 2020, 'Ancient Genomic Regulatory Blocks Are a Source for Regulatory Gene Deserts in Vertebrates after Whole-Genome Duplications', Molecular Biology And Evolution, 37, 10, 2857 - 2864.

Selected research activities

- New funding:

* European Research Council Consolidator Grant.

* La Caixa Health Research Grant.


- Three PhD thesis defended (Antonio Torres-Mendez, Reza Sodaei, Victoria Rodriguez-Vaello).