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Manuel Irimia

Manuel Irimia

Centre de Regulació Genòmica

Life & Medical Sciences

Manuel Irimia obtained his PhD in 2010 at University of Barcelona investigating the origin of vertebrates at a genomic level. After two postdocs at Stanford University and University of Toronto, he joined the Centre for Genomic Regulation (CRG) in June 2014. He has been elected EMBO Young Investigator (2018) and obtained ERC Starting (2014) and Consolidator (2020) Grants.

Research interests

Manuel Irimia’s research is centered on two major questions: How does a single genome sequence encode the information to build the enormous complexity of cell types and structures of an adult organism? How are changes in this sequence translated into morphological novelties during evolution? To address these questions, his lab combines computational and experimental approaches using in vitro and in vivo systems (zebrafish, mouse and fruitfly) to investigate the roles of transcriptomic diversification and specialization in embryonic development and evolution.

Selected publications

– Martin, Guiomar; Marquez, Yamile; Mantica, Federica; Duque, Paula; Irimia, Manuel 2021, ‘Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals’, Genome Biology, 22, 1, 35.

– Hoijman, Esteban; Hakkinen, Hanna-Maria; Tolosa-Ramon, Queralt; Jimenez-Delgado, Senda; Wyatt, Chris; Miret-Cuesta, Marta; Irimia, Manuel; Callan-Jones, Andrew; Wieser, Stefan; Ruprecht, Verena 2021, ‘Cooperative epithelial phagocytosis enables error correction in the early embryo’, Nature, 590, 7847.

– Head, Sarah A.; Hernandez-Alias, Xavier; Yang, Jae-Seong; Ciampi, Ludovica; Beltran-Sastre, Violeta; Torres-Mendez, Antonio; Irimia, Manuel; Schaefer, Martin H.; Serrano, Luis 2021, ‘Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers’, Plos Biology, 19, 2, e3001138.

– Marquez, Yamile; Mantica, Federica; Cozzuto, Luca; Burguera, Demian; Hermoso-Pulido, Antonio; Ponomarenko, Julia; Roy, Scott W.; Irimia, Manuel 2021, ‘ExOrthist: a tool to infer exon orthologies at any evolutionary distance’, Genome Biology, 22, 1, 239.

– Elorza, Ainara; Marquez, Yamile; Cabrera, Jorge R.; Luis Sanchez-Trincado, Jose; Santos-Galindo, Maria; Hernandez, Ivo H.; Pico, Sara; Diaz-Hernandez, Juan, I; Garcia-Escudero, Ramon; Irimia, Manuel; Lucas, Jose J. 2021, ‘Huntington’s disease-specific mis-splicing unveils key effector genes and altered splicing factors’, Brain, 144, 7, 2009 – 2023.

Selected research activities

– La Caixa HR 2020, ERC Consolidator 2020 and Plan Estatal 2021 grants started.

– One PhD thesis defended (Laura Lopez-Blanch), two submitted (Simon Bajew and Patryk Polinski).

– 11 invited talks/seminars.

ICREA Memoir 2021