Gerardo Jiménez graduated in biology from Universitat de Barcelona in 1988. He performed his doctoral studies at the Leukaemia Research Fund in London and at the Department of Biochemistry of Universitat de Barcelona, working on the structure and regulation of mammalian globin gene loci. After receiving his PhD degree in 1993, he worked as a postdoctoral fellow at Cancer Research UK, both in Oxford and in London. Since then, his research interests have focused on the transcriptional and cell signaling mechanisms controlling gene expression during animal development, mainly using Drosophila as a model system. After his postdoctoral training, he moved to the Institut de Biologia Molecular de Barcelona-CSIC, where he is head of the Gene Expression and Signaling laboratory since 2002. He joined ICREA in 2003.
During animal development, the differentiation of cells, tissues and organs is tightly regulated through specific gene expression programs. Our research addresses the transcriptional and cell signaling mechanisms responsible for this control. Most of our work uses the fruit fly, Drosophila, which allows us to combine classical genetic, cell biological and biochemical approaches with genome-editing technologies such as CRISPR-Cas9. One main line of research focuses on Ras-Erk signaling and its downstream effector Capicua (Cic), an evolutionarily conserved transcriptional repressor with key roles in normal development and human diseases. We discovered this factor in Drosophila and are studying its function from different perspectives, including the analysis of its basic mechanism of repression and its interaction with Erk signaling and other signal transduction pathways. In addition, we have a long-term interest in transcriptional corepressors such as the conserved Groucho/TLE and Atrophin proteins, which we are analyzing from a functional and mechanistic point of view. Ultimately, our studies are aimed at defining basic cell biological mechanisms that are relevant to human disorders.
- Cuevas-Navarro A, Rodriguez-Muñoz L, Grego-Bessa J, Cheng A, Rauen KA, Urisman A, McCormick F, Jimenez G & Castel P 2022, ‘Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs’, eLife, 11, e76495.
- Rodríguez-Muñoz L, Lagares C, González-Crespo S, Castel P, Veraksa A & Jiménez G 2022, 'Noncanonical function of Capicua as a growth termination signal in Drosophila oogenesis', Proc Natl Acad Sci USA 19(31):e2123467119.
Selected research activities
- Principal investigator of research project “Transcriptional repression in Drosophila development” funded by MICINN (2021-2024).
- Director of Master thesis by Sofia Calpe Gómez, Universitat de Barcelona, August 2022.
- Invited speaker at 5th Spanish Conference on the Molecular, Cellular and Developmental Biology of Drosophila (Begur, Girona)
- Peer reviewer for international research journals (Science Advances and Development)