Núria López-Bigas

Núria López-Bigas

Institut de Recerca Biomèdica de Barcelona

Life & Medical Sciences

Núria López-Bigas has a PhD in Biology from the University of Barcelona and has expertise in Medical Genetics and in Computational Biology and Bioinformatics. During her PhD work, she studied the molecular causes of hereditary deafness at the group of Xavier Estivill. Next she moved to the European Bioinformatics Institute in Hinxton (Cambridge, UK) to work on Computational Genomics at the group of Christos A. Ouzounis and then at the Center for Regulatory Genomics (Barcelona) at the group of Roderic Guigó. Núria joined the Pompeu Fabra University in April 2006 with a Ramón y Cajal Position, was appointed ICREA Research Professor in October 2011 and her lab moved to Institute for Research in Biomedicine in November 2016. She leads the Biomedical Genomics Research Group (http://bbglab.irbbarcelona.org). In 2015 she was awarded an ERC Consolidator Grant.

Research interests

Núria López-Bigas research is focused on the study of cancer from a genomics perspective. She is particularly interested in the identification of cancer driver mutations, genes and pathways across tumor types and in understanding the mutational processes leading to accumulation of mutations in tumors. Among the most important achievements obtained by Lopez-Bigas’ lab are the development of pioneer methods to identify driver genes (Oncodrive methods), the creation of IntOGen (http://www.intogen.org), a discovery tool for cancer research, the discovery that protein-bound DNA impairs nucleotide excision repair (Radhakrishnan et al., 2016), the finding that exons have reduced mutation rate due to differential mismatch repair (Frigola et al., 2017), the discovery that nucleosome covered DNA shows a 10 bp periodicity on the rate of somatic and germline mutations (Pich et al., 2018), and the identification of the mutational footprints of cancer therapies (Pich et al., 2019).

Selected publications

– Hernández-Sánchez M, Kotaskova J, Rodríguez AE, Radova L, Tamborero D, Abáigar M, Plevova K, Benito R, Tom N, Quijada-Álamo M, Bikos V, Martín AÁ, Pal K, García de Coca A, Doubek M, López-Bigas N, Hernández-Rivas JM & Pospisilova S 2019, ‘CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase Comprehensive Characterization of Cancer Driver Genes and Mutations‘, Leukemia, 33, 2, 518 – 522.

– Pich O, Muiños F, Lolkema MP, Steeghs N, Gonzalez-Perez A & Lopez-Bigas N 2019, ‘The mutational footprints of cancer therapies‘, Nature Genetics, 51, 12, 1732-1740

– Martínez-Jiménez F, Muiños F, López-Arribillaga E, López-Bigas N & González-Pérez A 2019, ‘Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer‘, Nature Cancer, s43018-019-0001-2

– Gonzalez-Perez A, Sabarinathan R & Lopez-Bigas N 2019, ‘Local Determinants of the Mutational Landscape of the Human Genome‘, Cell, 177 (1):101-114.

– Arnedo-Pac C, Mularoni L, Muinos F, Gonzalez-Perez A & Lopez-Bigas N 2019, ‘OncodriveCLUSTL: a sequence-based clustering method to identify cancer divers’, Bioinformatics, 35, 22, 4788-4790.

Selected research activities

Chair for Advances in Computational Biology Conference 2019. Fostering collaboration among women scientists. Barcelona, Nov 28 – 29, 2019.

Co-organizer of EMBL Cancer Genomics Conference 2019, 4-6 November. Heidelberg, Germany

Invited speaker at: – EACR conference. Defence is the Best Attack: Immuno-Oncology Breakthroughs. Barcelona – Heterogeneity and Evolution in Cancer Conference at CNIO, Madrid – Medical Genetics Session, New Horizons in Genomics, QMUL London – and others

Keynote Speaker at First Zürich Precision Oncology Symposium, Comprehensive Cancer Center Zürich (Switzerland)

Chair of the Research Integrity Committee at the Institute for Research in Biomedicine

Board member of the Spanish Society Against Cancer (AECC)

National “Doctores Diz Pintado” Cancer Research Prize