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Marc Martí-Renom

Marc Martí-Renom

Centre de Regulació Genòmica

Life & Medical Sciences

I obtained a Ph.D. in Biophysics from the UAB where I worked on protein folding under the supervision of Professors B. Oliva, F.X. Avilés and M. Karplus (Nobel Laureate in 2013). After that, I went to the US for a postdoctoral training on protein structure modeling at the Sali Lab (Rockefeller University) as the recipient of the Burroughs Wellcome Fund fellowship. Later on, I was appointed Assistant Adjunct Professor at UCSF. Between 2006 and 2011, I headed the Structural Genomics Group at the CIPF in Valencia (Spain). Since October 2013, I am ICREA Research Professor and lead the Structural Genomics Group at the CNAG-CRG. Our group is broadly interested on how chromatin organizes and regulates cell fate. I have published over 135 articles in international peer-reviewed journals with over 20,000 citations (Google Scholar indexed).

Research interests

How biomolecules fold and function in a three-dimensional space is one of the most challenging questions in biology. For example, we have limited knowledge on how the 2-meter-long DNA molecule folds in the micro-sized nucleus or how RNA, proteins and small chemical compounds fold and interact to perform their most basic functions of the cell. Our research group employ the laws of physics and the rules of evolution to develop and apply experimental and computational methods for predicting the 3D structures of macromolecules and their complexes.

Selected publications

– Farabella, Irene; Di Stefano, Marco; Soler-Vila, Paula; Marti-Marimon, Maria; Marti-Renom, Marc A. 2021, ‘Three-dimensional genome organization via triplex-forming RNAs’, Nature Structural & Molecular Biology, 28, 11, 945 – +.

– Di Stefano, Marco; Paulsen, Jonas; Jost, Daniel; Marti-Renom, Marc A. 2021, ‘4D nucleome modeling’, Current Opinion In Genetics & Development, 67, 25 – 32.

– Richart, Laia; Lapi, Eleonora; Pancaldi, Vera; Cuenca-Ardura, Mirabai; Carrillo-de-Santa Pau, Enrique; Madrid-Mencia, Miguel; Neyret-Kahn, Helene; Radvanyi, Francois; Antonio Rodriguez, Juan; Cuartero, Yasmina; Serra, Francois; Le Dily, Francois; Valencia, Alfonso; Marti-Renom, Marc A.*; Real, Francisco X.* (*shared senior authorship) 2021, ‘STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells’, Nucleic Acids Research, 49, 19, 11005 – 11021.

– Vilarrasa-Blasi R, Soler-Vila P, Verdaguer-Dot N, Russiñol N, Di Stefano M, Chapaprieta V, Clot G, Farabella I, Cuscó P, Kulis M, Agirre X, Prosper F, Beekman R, Beà S, Colomer D, Stunnenberg HG, Gut I, Campo E, Marti-Renom MA*, Martin-Subero JI* (*shared senior authorship) 2021, ‘Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation’, Nature Communications, 12, 1, 651.

– Mendieta-Esteban, Julen; Di Stefano, Marco; Castillo, David; Farabella, Irene; Marti-Renom, Marc A. 2021, ‘3D reconstruction of genomic regions from sparse interaction data’, Nar Genomics And Bioinformatics, 3, 1.

Selected research activities

ICREA Memoir 2021