I am a developmental biologist. Over the last fifteen years my work has focused on using Embryonic Stem Cells (ESCs) to explore cell fate decisions during mammalian development. Recently, we have developed a novel experimental system which is changing the way to study early mammalian development. Defined numbers of mouse ESCs are aggregated in controlled culture conditions and over time develop structures that mimic the organization of the vertebrate embryo; we call them ‘gastruloids’ because they mirror the process of gastrulation. This system is opening up unforeseen experimental possibilities for studies of mammalian development whose embryos, particularly at the crucial early stages, are difficult to access. Recently we have successfully extended this work to human ESCs and obtained human gastruloids which mimic the postgastrulation body plan thus opening up the possibility to, for the first time, study the process of gastrulation and its consequences in humans.
Alfonso was born in Madrid (Spain) and obtained his undergraduate degree at the Universidad Complutense in Madrid (Spain) in 1977 and, in 1983, a PhD from the University of Chicago, Chicago (USA). After a postdoc with Peter Lawrence at the MRC LMB in Cambridge became a Wellcome Trust Senior Fellow and since 2003 until 2021, has been Professor of Developmental Mechanics in the Department of Genetics of the University of Cambridge, Cambridge (UK) working on developmental biology with the fruit fly (Drosophila) and more recently Embryonic Stem Cells. His interests cover the interface of cell and developmental biology with Physics and Engineering. He is a member of EMBO, has been awarded two ERC Advanced Investigator grants and in 2012 received the Waddington medal of the BSDB for his contributions to british developmental biology.
- Arias AM, Marikawa Y & Moris N 2022, 'Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering', Developmental Biology, 488, 35 - 46.
- Hashmi A, Tlili S, Perrin P, et al. 2022, 'Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids', Elife, 11, e59371.
- Salmen F, De Jonghe J, Kaminski TS, et al. 2022, 'High-throughput total RNA sequencing in single cells using VASA-seq', Nature Biotechnology, 40(12), 1780-1793.
- Hashmi A, Tlili S, Perrin P, Lowndes M, Peradziryi H, Brickman JM, Martínez Arias A & Lenne PF 2022, 'Cell states transitions and collective cell movement generate an endoderm-like region in gastruloids', eLife, 11:e59371.
- Arias AM, Marikawa Y & Moris N 2022, 'Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering', Dev Biol., 488:35-46.