CURRENT POSITIONS:

RESEARCH FUNDING:

OTHER WEBSITES: IDIBAPS website

SOCIAL MEDIA HANDLES: Twitter/X and Bluesky: @GeneRegLab

Our group studies the molecular mechanisms that regulate cell and metabolic plasticity in health and disease, with a particular focus on transcriptional regulation. Our ultimate goal is to define markers for tracking disease onset and progression and to inform new therapeutic approaches aimed at restoring normal gene expression and function. Ongoing projects investigate gene regulation and immunometabolism in inflammation, cancer initiation and progression, stem cell determination and differentiation, and tissue injury and regeneration.

We employ a wide range of technical approaches, including unique conditional transgenic mice, ex vivo culture and gene manipulation of normal and malignant primary cells, differentiation of human embryonic stem cells, and high-throughput Omics techniques (RNAseq, scRNAseq, metabolomics). As molecular models, we utilize the EMT transcription factors ZEB1 and ZEB2, which play key roles in the regulation of cell plasticity.