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Antonio Postigo

Antonio Postigo

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Life & Medical Sciences

CURRENT POSITIONS:  * ICREA Professor of Life & Medical Sciences. IDIBAPS Research Institute (Barcelona) * Adjunct Visiting Professor, JG Brown Cancer Center, Univ. Louisville School of Medicine (USA) * Adjunct Lecturer, Dept. of Biomedicine. Univ. of Barcelona School of Medicine (Barcelona) RESEARCH FUNDING:  * Public Agencies: European Commission / National Research Agency - Spanish Ministry of Science & Innovation / Catalan Agency for University & Research Grants (AGAUR) * Private Foundations: Leukemia Research Foundation / Duchenne Parent Project / AVON Breast Cancer Campaign / Spanish Association Against Cancer (AECC) / La Marató TV3 Foundation / Olga Torres Foundation / La Caixa Foundation / Catalan Academy of Medical & Health Sciences. OTHER WEBSITES & SOCIAL MEDIA HANDLES: IDIBAPS:  Twitter: @GeneRegLab

Research interests

Our group studies the molecular mechanisms that regulate cell plasticity in health and disease with a particular focus on transcriptional regulation. Ongoing projects investigate gene regulation in inflammation, cancer initiation and progression, stem cell determination and differentiation, and tissue injury and regeneration. We use a wide range of technical approaches that include unique conditional transgenic mice, ex vivo culture and manipulation of normal and malignant primary cells, differentiation of human embryonic stem cells, and high-throughput techniques (e.g., RNAseq, scRNAseq, proteomics). As molecular models, we use the EMT transcription factors ZEB1 and ZEB2 which play key roles in the regulation of cell plasticity.

Selected publications

– Guo Y, X Lu, Y Chen, B Rendon, RA Mitchell, M Cuatrecasas, M Cortés, A POSTIGO *, Y Liu *, DC Dean * (2021). ZEB1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells. Science Advances. 7:eabd7455 (* equal co-corresponding authors). Impact Factor: 14.14

Selected research activities

* Director of PhD dissertations that were defended during 2021

Maria Carmen Martinez Campanario (Univ of Barcelona), PhD awarded in May 2021


* Patents Submitted during 2021

Cancer informative biomarker signature IMMETCOLS (Reference Spanish/EU patent office P5886EP00). August 2021

ICREA Memoir 2021