Javier Ramón Azcón

Javier Ramón Azcón

Institut de Bioenginyeria de Catalunya

Engineering Sciences

Since 2017, ICREA Professor Javier Ramon has been a Group Leader at the Institute of Bioengineering of Catalonia (IBEC) in Barcelona, Spain. After his doctorate, he performed a post-doc stay under professor Mizutani's direction at Hyogo University in Japan on lithography fabrication, microfluidics, and dielectrophoresis technic (2009-2011). After this post-doctoral stay at Hyogo University (2011), he was hired by the Advanced Institute for Materials Research (AIMR) at Tohoku University as Assistant Researcher. The AIMR-WPI institute is the third most relevant institute in Japan and one worldwide reference in material science. He joined the group of Prof. Matsue in the device/ systems group, and in April 2013, he was promoted to Assistant Professor. In this position, he worked to integrate biosensor technology with stem cells, biomaterials, and tissue engineering research (2011-2014).

Research interests

My group ‘Biosensors for Bioengineering’ is focused on a new line of research that has become of extreme importance in the last years. My idea is to integrate biosensor technology and nanotechnology with stem cell research and tissue engineering. Engineered tissues are integrated with biosensing technology to obtain microdevices (microtissues and ‘Multi-Organ-on-a-Chip’ (multi-OOC)) to detect cellular responses to external stimuli, monitor the quality of the microenvironment, and support diverse cellular requirements. This research on 3D-functional engineered tissues is expected to develop tissue construction knowledge and their functions and relation to some human diseases. Integration of fully functional tissues with microscale biosensor technology allowed us to obtain OOC. These chips could be used in pharmaceutical assays. They could be a step toward the ultimate goal of producing in vitro drug testing systems crucial to the medicine and pharmaceutical industry.

Selected publications

- Mughal S, Sabater-Arcis M, Artero R, Ramon-Azcon J & Fernandez-Costa JM 2024, 'Taurine activates the AKT-mTOR axis to restore muscle mass and contractile strength in human 3D in vitro models of steroid myopathy', Disease models & mechanisms, 17 - 4 -dmm050540.
- Miñana AF, Alcaraz E, Horrillo R, Azcon JR & De Chiara F 2024, '3D bioengineered liver for the study of acute and chronic hepatic damage', Journal of hepatology, 80 - 1 - S46 - S46.
- Ninfali C, Fernández-Garibay X, Tejedera-Villafranca A, Díaz-Manera J, Ramón-Azcón J & Fernández-Costa J 2024, 'Duchenne muscular dystrophy fibro-adipogenic progenitors impair muscle function of co-cultured healthy myotubes in a functional 3D model', Neuromuscular disorders, 43.
- Fernández-Garibay X, Sabater-Arcís M, Núñez-Manchón J, Tejedera-Villafranca A, Artero R, Suelves M, Nogales-Gadea G, Ramón-Azcón J & Fernández-Costa J 2024, 'Advancing preclinical research of myotonic dystrophy type 1 with 3D functional human skeletal muscle tissues', Neuromuscular disorders, 43.

Selected research activities

I am one of the founders and vice president of the Spanish Society of Microphysiological Systems and Organ-on-Chip (SESMOoC). The Spanish Society of Microphysiological Systems and Organ-on-Chip is a multidisciplinary scientific association aimed at enhancing the visibility of Organ-on-Chip technology and microphysiological systems in Spain through a scientific society that unites leading researchers in the field, fostering credibility and trust. Additionally, it seeks to serve as a unifying forum for individuals engaged in scientific and technical work across all disciplines related to Organ-on-Chip technology or microphysiological systems. This includes research in microfluidics, microtechnologies, microfabrication, sensors, materials and biomaterials, cell biology, organoids, pathophysiology, additive manufacturing, bioprinting, computational simulation, and more.