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Javier Ramón

Javier Ramón

Institut de Bioenginyeria de Catalunya

Engineering Sciences

Since 2017, ICREA Professor Javier Ramon is a Group Leader at the Institute of Bioengineering of Catalonia (IBEC) in Barcelona, Spain. After her doctorate, he performed a post-doc stay under professor Mizutani's direction at Hyogo University in Japan on lithography fabrication, microfluidics, and dielectrophoresis technic (2009-2011). After this post-doctoral stay at Hyogo University (2011), he was hired by the Advanced Institute for Materials Research (AIMR) at Tohoku University as Assistant Researcher. The AIMR-WPI institute is the third most relevant institute in Japan and one worldwide reference in material science. He joined the group of Prof. Matsue in the device/ systems group, and in April 2013, he was promoted to Assistant Professor. In this position, he worked to integrate biosensors technology with stem cell, biomaterials, and tissue engineering research (2011-2014).

Research interests

My group ‘Biosensors for Bioengineering’ is focused on a new line of research that has become of extreme importance in the last years. My idea is to integrate biosensor technology and nanotechnology with stem cell research and with tissue engineering. Engineered tissues are integrated with biosensing technology to obtain microdevices (microtissues and ‘Multi-Organ-on-a-Chip’ (multi-OOC)) to detect cellular responses to external stimuli, monitoring the quality of the microenvironment, and supporting diverse cellular requirements. This research on 3D-functional engineered tissues is expected to develop tissue construction knowledge and their functions and relation with some human diseases. Integration of fully functional tissues with microscale biosensor technology allowed us to obtain OOC. These chips could be used in pharmaceutical assays. They could be a step toward the ultimate goal of producing in vitro drug testing systems crucial to the medicine and pharmaceutical industry.

Selected publications

– De Chiara, Francesco; Ferret-Minana, Ainhoa; Ramon-Azcon, Javier 2021, ‘The Synergy between Organ-on-a-Chip and Artificial Intelligence for the Study of NAFLD: From Basic Science to Clinical Research’, Biomedicines, 9, 3, 248.

– Fernandez-Garibay, Xiomara; Ortega, Maria A.; Cerro-Herreros, Estefania; Comelles, Jordi; Martinez, Elena; Artero, Ruben; Fernandez-Costa, Juan M.; Ramon-Azcon, Javier 2021, ‘Bioengineered in vitro 3D model of myotonic dystrophy type 1 human skeletal muscle’, Biofabrication, 13, 3, 035035.

– Velasco-Mallorqui, Ferran; Rodriguez-Comas, Julia; Ramon-Azcon, Javier 2021, ‘Cellulose-based scaffolds enhance pseudoislets formation and functionality’, Biofabrication, 13, 3, 035044.

– Nashimoto, Yuji; Abe, Minori; Fujii, Ryota; Taira, Noriko; Ida, Hiroki; Takahashi, Yasufumi; Ino, Kosuke; Ramon-Azcon, Javier; Shiku, Hitoshi 2021, ‘Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies’, Advanced Healthcare Materials, 2101186.

– Lopez-Munoz, Gerardo A.; Fernandez-Costa, Juan M.; Alejandra Ortega, Maria; Balaguer-Trias, Jordina; Martin-Lasierra, Eduard; Ramon-Azcon, Javier 2021, ‘Plasmonic nanocrystals on polycarbonate substrates for direct and label-free biodetection of Interleukin-6 in bioengineered 3D skeletal muscles’, Nanophotonics, 10, 18, 4477 – 4488.

– Vila, Judith Camalo; Castro-Aguirre, Nerea; Lopez-Munoz, Gerardo A.; Ferret-Minana, Ainhoa; De Chiara, Francesco; Ramon-Azcon, Javier 2021, ‘Disposable Polymeric Nanostructured Plasmonic Biosensors for Cell Culture Adhesion Monitoring’, Frontiers In Bioengineering And Biotechnology, 9, 799325.

ICREA Memoir 2021