Ángel Raya is an ICREA Research Professor at the Bellvitge Biomedical Research Institute (IDIBELL). He obtained his MD in 1990 from the University of Valencia, Spain and a PhD degree from the same university in 1995 for studies carried out at the Department of Physiology and at the Department of Neurology, Mayo Clinic, Rochester, MN. He pursued postdoctoral training at the Instituto de Investigaciones Citológicas (currently, Centro de Investigación Príncipe Felipe) in Valencia, from 1995-2000. He then was a Research Associate (2000-2004) and a Senior Research Associate (2004-2006) in the Gene Expression Laboratory of the Salk Institute for Biological Studies, La Jolla, CA. He returned to Spain in 2006 and was the Scientific Coordinator at the CMRB until 2009, when he joined the Institute for Bioengineering of Catalonia (IBEC) as Group Leader of the Control of Stem Cell Potency group, until 2015. From 2014 to 2019 he was Director at CMRB.
Research interests
Our research work aims to understand the tissue, cellular and molecular mechanisms that determine the regenerative response in certain species of vertebrates, as well as the genetic and epigenetic mechanisms that control cellular reprogramming. This phenomenon provides a link between the traditional study of epimorphic regeneration and the induced pluripotency strategies of regenerative medicine.
Selected publications
- Escribá R, Larrañaga-Moreira JM, Richaud-Patin Y, ..., Raya A. 2023, 'iPSC-Based Modeling of Variable Clinical Presentation in Hypertrophic Cardiomyopathy', Circ Res, 133, 2, 108 - 119.
- Siguero-Álvarez M, Salguero-Jiménez A, ..., Raya A, Gimeno-Blanes JR, de la Pompa JL. 2023, 'A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve', Circulation, 147, 1, 47 - 65.
- Tristán-Noguero A, Fernández-Carasa I, ..., Raya A, García-Cazorla A, Consiglio A. 2023, 'iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation', EMBO Mol Med, 15, 3, e15847.
- Pesce M, Duda G, Forte G, Girao H, Raya A, Roca-Cusachs P, Sluijter J, Tschöpe C, Van Linthout S. 2023, 'Cardiac fibroblasts and mechanosensation in heart development, health and disease', Nat Rev Cardiol, 20:309–324.
- Kuebler B, ... Raya A, Giner SQ & Veiga A 2023, 'Generation of a bank of clinical-grade, HLA-homozygous iPSC lines with high coverage of the Spanish population', Stem Cell Res Ther, 14 - 1.
- Reinal I, Ontoria-Oviedo I, ..., Raya A, Sepúlveda P. 2023, 'Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs', Antioxidants, 12, 7, 1378.
Selected research activities
Co-organizer
First RegenBell symposium on Stem Cells and Regenerative Medicine, Institut d’Estudis Catalans, Barcelona, Nov
Keynote speaker
Kick-off meeting COST Action CA21151-HAPLO-iPS, Barcelona, Jan
Invited speaker
Ciclo de Conferencias Científicas – Universitat de Valencia, Feb
35è Congrés de la Societat Cat Cardiologia, Barcelona, Jun
CIBER-BBN-EHD Annual Conference, Santander, Nov