Ángel Raya is an ICREA Research Professor at the Bellvitge Biomedical Research Institute (IDIBELL). He obtained his MD in 1990 from the University of Valencia, Spain and a PhD degree from the same university in 1995 for studies carried out at the Department of Physiology and at the Department of Neurology, Mayo Clinic, Rochester, MN. He pursued postdoctoral training at the Instituto de Investigaciones Citológicas (currently, Centro de Investigación Príncipe Felipe) in Valencia, from 1995-2000. He then was a Research Associate (2000-2004) and a Senior Research Associate (2004-2006) in the Gene Expression Laboratory of the Salk Institute for Biological Studies, La Jolla, CA. He returned to Spain in 2006 and was the Scientific Coordinator at the CMRB until 2009, when he joined the Institute for Bioengineering of Catalonia (IBEC) as Group Leader of the Control of Stem Cell Potency group, until 2015. From 2014 to 2019 he was Director at CMRB.
Research interests
Our research work aims to understand the tissue, cellular and molecular mechanisms that determine the regenerative response in certain species of vertebrates, as well as the genetic and epigenetic mechanisms that control cellular reprogramming. This phenomenon provides a link between the traditional study of epimorphic regeneration and the induced pluripotency strategies of regenerative medicine.
Selected publications
- Pourchet L, Casado-Medina L, Richaud-Patin Y, Tadevosyan K, Morillas-Garcia A, Lorenzo E, Lazis I, Ventura A, Litowczenko J, Guiu J & Raya A 2025, '3D bioprinting of human iPSC-derived cardiac constructs with microvascular network support for improved graft survival in vivo', Biofabrication, 17 - 3 - 035010.
- Hernández-Muñoz, I et al. 2025, 'EWS::FLI1 expression in human embryonic mesenchymal stem cells leads to transcriptional reprograming, defective DNA damage repair and Ewing sarcoma', Nature communications, 16 - 1 - 9427.
- Blasco-Agell, L et al. 2025, 'LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson's disease model', Communications biology, 8 - 1 -1203.
- Calle, X et al. 2025, '17-beta estradiol prevents cardiac myocyte hypertrophy by regulating mitochondrial E3 ubiquitin ligase 1', Cell death & disease, 16 - 1 - 111.
- Espín, R et al. 2025, 'Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment', Nar cancer, 7 - 1 -zcaf007.
- López-González, V et al. 2025, 'DYRK1A haploinsufficiency syndrome. Clinical and molecular characterization of 33 new cases', European journal of human genetics, 33 - 755 - 756.
Selected research activities
Co-organizer
Joint Session Translational & Regenerative Medicine, IDIBELL, Barcelona, Jan
2025 RegenBell symposium on Stem Cells and Regenerative Medicine, Institut d’Estudis Catalans, Barcelona, Nov
Keynote speaker
Kick-off meeting COST Action CA21151-HAPLO-iPS, Barcelona, Jan
III Congreso Estudiantes Biomedicina – CEBUIC, Sant Cugat Del Vallès, Jul
IUBMB Opening Lecture, XLVIII Annual Meeting SBBMCh, La Serena, Chile, Oct
Invited speaker
IDIBELL Faculty Seminars, Barcelona, June
I Scientific Meeting CIBERBBN/INFEC, Sevilla, Nov
HAPLO-iPS –GAiT Workshop, London, Dec