Lluís Ribas de Pouplana

Lluís Ribas de Pouplana

Institut de Recerca Biomèdica

Life & Medical Sciences

Born in Girona. He studied Biology at the University of Barcelona, and Biochemistry at Edinburgh University, where he obtained a PhD in 1992 with the help of a fellowship from La Caixa/British Council. He then joined the Biology department of the Massachusetts Institute of Technology as a postdoc. In 1997 he moved to The Scripps Research Institute where he became assistant professor of Molecular Biology in 2001. In 2003 he joined ICREA, and became Principal Investigator at the Institute for Research in Biomedicine, where he heads the Laboratory of Gene Translation. He is the founder of two biotechnology companies and has acted as Chief Scientific Officer of Omnia Molecular SL. (2010-2015). In addition, Dr. Ribas serves as Editor-in-Chief of the journal Life and is an elected member of the 'Institut d'Estudis Catalans'.

Research interests

Our laboratory investigates the process of protein synthesis, its evolution, and its connections to human health. We are preoccupied by two fundamental questions: what are the functional limits of the protein synthesis apparatus, and how is protein synthesis regulated and integrated within the context of the cell. We want to understand what defines the boundaries of the proteomes, and how alterations to the machinery that turns genes into proteins affect human health and aging. In addition, we are studying protein synthesis in the mitochondria, with a particular emphasis on the mechanisms that coordinate mitochondrial protein synthesis to mitochondrial dynamics and cell cycle. How these biosynthetic routes are coordinated, and how are they synchronized with the cell cycle is unknown.

Selected publications

- Murillo-Recio M, Martínez de Lejarza Samper IM, Tuñí i Domínguez C, Ribas de Pouplana L & Torres AG 2023, 'tRNAstudio: facilitating the study of human mature tRNAs from deep sequencing datasets', Bioinformatics, 38, 10, 2934 - 2936.


- Ribas de Pouplana L 2023, 'Archeal tRNA meets biotechnology: From vaccines to genetic code expansion', J Biol Chem, 299(1), 102755.

- Xie SC, Griffin MDW, Winzeler EA, Ribas de Pouplana L & Tilley L 2023, 'Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development', Annual Reviews of Microbiology, 77, 111-129, 37018842.