César  Rodriguez Emmenegger

César Rodriguez Emmenegger

Institut de Bioenginyeria de Catalunya

Engineering Sciences

César was born in Salto, Uruguay. After studying Chemical Engineering (2001—2006) in the Universidad de la República, Uruguay, he was awarded a research UNESCO-IUPAC internship (2006-2007) in the Institute of Macromolecular Chemistry in Prague where he got hooked in the topic of polymers and biointerfaces. There he pursued his PhD (2007—2012) working on optical biosensors and antifouling surfaces under the mentorship of Eduard Brynda and Aldo Bologna. Following a postdoctoral work (A. von Humboldt postdoctoral fellowship, 2012-2013), and research stays in Melville Laboratory in Cambridge (2009), Univ. of Pennsylvania (2013, 2015), and Pasteur Institute in Lille (2015), César returned to Prague to start his independent group. In January 2016, his group joined DWI-Leibniz Institute for Interactive Materials in Aachen and expanded the research to adaptive interfaces and synthetic cells. Currently, he is an ICREA Research Professor at the Institute of Bioengineering of Catalonia.

Research interests

We want to uncover design rules to develop materials capable of communicating with living matter and directing its behavior in a self-regulated manner to enable new biomaterials, therapeutics, and medical devices. Research lines: (1) Molecular Engineering. We imitate nature blueprints to synthetize macromolecules that like “Lego” pieces assemble into structures with totally new functions. (2) Stealth and adaptive biointerfaces. We are developing adaptive coatings that interact and direct the biological surrounding in a self-regulated manner and their translation to medical and diagnostic applications. This includes hemocompatible surfaces, wound dressings, etc. (3) Cell membrane mimics and protocellular systems. We working on “quasi-living” synthetic cells by assembling non-living modules into micro-compartments displaying similar functionality and adaptivity as found in natural cells and beyond. An example are synthetic macrophages to fight antibiotic-resistant pathogens

Selected publications

Macromolecular Chemistry and Physics, 224, 24, 2300306.
Langmuir, 39, 50, 18476–18485.
- Wagner AM, Kostina NY, Xiao Q, Klein ML, Percec V & Rodriguez-Emmenegger C 2023, 'Glycan-Driven Formation of Raft-Like Domains with Hierarchical Periodic Nanoarrays on Dendrimersome Synthetic Cells', Biomacromolecules, 25 - 1 - 366 - 378.
- Witzdam L, Garay-Sarmiento M, Gagliardi M, Meurer YL, Rutsch Y, Englert J, Philipsen S, Janem A, Alsheghri R, Jakob F, Molin DGM, Schwaneberg U, van den Akker NMS & Rodriguez-Emmenegger C 2023 'Brush-Like Coatings Provide a Cloak of Invisibility to Titanium Implants', Macromolecular bioscience, - - -

- Witzdam, Lena; Vosberg, Berlind; Grosse-Berkenbusch, Katharina; Stoppelkamp, Sandra; Wendel, Hans Peter; Rodriguez-Emmenegger, Cesar 2023, 'Tackling the Root Cause of Surface-Induced Coagulation: Inhibition of FXII Activation to Mitigate Coagulation Propagation and Prevent Clotting', Macromolecular Bioscience, .

- Zhang D, Xiao Q, Rahimzadeh M, et al. 2023, 'Self-Assembly of Glycerol-Amphiphilic Janus Dendrimers Amplifies and Indicates Principles for the Selection of Stereochemistry by Biological Membranes', Journal Of The American Chemical Society, 145, 7, 4311-4323.