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Angel R. Nebreda

Angel R. Nebreda

Institut de Recerca Biomèdica

Life & Medical Sciences

Angel R. Nebreda obtained his PhD in Molecular Biology from the University of Salamanca (Spain) and then worked as a postdoc at the National Institutes of Health in Bethesda (USA) and the Cancer Research-UK Clare Hall Laboratories in South Mimms (UK). In 1995, he started his own group at the European Molecular Biology Laboratory in Heidelberg (Germany) where he worked for 9 years and then moved to the newly created Centro Nacional de Investigaciones Oncológicas in Madrid. He is currently an ICREA Research Professor at the Institute for Research in Biomedicine in Barcelona, where he leads a multidisciplinary team with expertise in biochemistry and molecular and cellular biology techniques, as well as in genetically modified mice and preclinical cancer models. He was elected EMBO member in 2003 and has obtained ERC Advanced and Proof of Concept grants.

Research interests

We investigate mechanisms that allow the cells to interpret stress signals and elaborate the appropriate responses. Our work focuses on signal integration by p38 MAPKs, addressing physiological functions and their roles in tumorigenesis. The main interests of the group are cancer cell homeostasis and chemoresistance mechanisms, the cross talk between cancer cells and stromal cells, and targeted therapies. We use a combination of biochemical approaches and studies with both established cell lines and primary cell cultures, as well as in vivo experiments using genetically modified mice, which allow the regulation of p38 MAPK signaling in a tissue-specific manner. We are interested in the identification of therapeutic opportunities based on the modulation of p38 MAPK activity using chemical compounds. Moreover, we study the regulation and functions of the RINGO proteins, a family of atypical activators of the cell cycle kinases Cdk1 and Cdk2.

Selected publications

– Canovas, Begoña; Nebreda, Angel R. 2021, ‘Diversity and versatility of p38 kinase signalling in health and disease‘, Nature Reviews Molecular Cell Biology, 22, 346-366.

– Gutierrez-Prat, Nuria; Cubillos-Rojas, Monica; Canovas, Begona; Kuzmanic, Antonija; Gupta, Jalaj; Igea, Ana; Llonch, Elisabet; Gaestel, Matthias; Nebreda, Angel R. 2021, ‘MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate‘, Proceedings Of The National Academy Of Sciences Of The United States Of America, 118, e2024562118.

Nebreda, Angel R.; Barral, Yves 2021, ‘Demixing the cell: how cells channel and store signaling information‘, Current Opinion In Cell Biology, 69, III – V.

Selected research activities

Guest Editor, 2021 “Cell Signalling” issue of Current Opinion in Cell Biology

ICREA Memoir 2021