Carme Rovira Virgili

Carme Rovira Virgili

Universitat de Barcelona

Experimental Sciences & Mathematics

Dr. Carme Rovira is an ICREA Research Professor at the University of Barcelona (UB). She obtained her PhD in Chemistry from UB in 1995, after completing part of her doctoral work in the United States. She then carried out postdoctoral research at the Max Planck Institute for Solid State Research in Stuttgart (1996–1998, with Prof. M. Parrinello) and the UB (1999–2001, with Prof. J. J. Novoa). In 2002, she was awarded a Ramón y Cajal Fellowship and established her group at the Parc Científic de Barcelona. She has been an ICREA Research Professor since 2007.
Dr. Rovira has received the Distinció de la Generalitat de Catalunya (2003), the Barcelona City Prize (2016), and the Emil Fischer Award of the European Carbohydrate Organization (2019). She is a recipient of an ERC Synergy Grant (2020), an elected member of the Royal Academy of Sciences and Arts of Barcelona, and the author of more than 200 publications in theoretical chemistry and computational biology.

Research interests

Dr. Rovira’s group applies and develops computational chemistry protocols and methods to investigate enzyme catalysis at atomic and electronic resolution. Current efforts focus on elucidating the chemical mechanisms of carbohydrate-active enzymes and other disease-related targets, with the aim of enabling the rational design of inhibitors, modulators, and activity-based probes.

Selected publications

- Rivas-Fernández JP, Vuillemin M, Pilgaard B, Klau LJ, Fredslund F, Lund-Hanssen C, Welner DH, Meyer AS, Morth JP, Meilleur F, Aachmann FL, Rovira C & Wilkens C 2025, 'Unraveling the molecular mechanism of polysaccharide lyases for efficient alginate degradation', Nature communications, 16 - 1 - 2670.
- Pichler MJ, Corbella M, Meier S, Andersen MHB, Nielsen TS, Banerjee S, Morth JP, Rovira C & Abou Hachem M 2025, 'A Minimal Mutation Trajectory Separates Inverting and Retaining Mechanisms on the Same Sialidase Structural Scaffold', Acs catalysis. 15, 9364–9378.
- Tandrup T, Rivas-Fernández JP, Madsen M, Ronne ME, Petersen AB, Klau LJ, Tondervik A, Wilkens C, Aachmann FL, Rovira C & Svensson B 2025, 'The Swiss Army Knife of Alginate Metabolism: Mechanistic Analysis of a Mixed-Function Polysaccharide Lyase/Epimerase of the Human Gut Microbiota', Journal of the american chemical society. 147, 23594–23607.
- Lagunas A, ... , Rovira C, De la Rosa MA, Díaz-Moreno I & Gorostiza P 2025, 'Long-Distance Charge Transport between Cytochrome c and Complex III is Mediated by Protons and Reactive Oxygen Species', Small, 21, 42, e01286.

Selected research activities

  • Invited talks at: Recent Advances in Modelling Rare Events (India), WATOC (Norway), the Brazilian Society for Biochemistry and Molecular Biology (Brazil), World Association of Theoretical and Computational Chemists (Norway), Beilstein Glyco-bioinformatics Symposium (Germany). Plenary talk at ChemBioVII (Sevilla).
  • Chair of Gordon research Conference Power Hour (USA)
  • Associate Editor of ACS Omega (Sept 2025 -)