Iñaki Ruiz-Trillo

Iñaki Ruiz-Trillo

Institut de Biologia Evolutiva

Life & Medical Sciences

Iñaki Ruiz-Trillo is an ICREA Research Professor at the Institut de Biologia Evolutiva (CSIC-UPF). His educational background includes a B.S. and a Ph.D. in Biology from the University of Barcelona. Funded by grants from EMBO and the Canadian Institutes of Health Research, he completed a post-doctoral fellowship at Dalhousie University (Canada). He has also performed short term research projects at the Joint Genome Institute, the University of Arkansas and the Kavli Institute for Theoretical Physics. Iñaki has published more than 80 peer-reviewed articles, most of them in high impact journals, such as Cell, Science, eLife, MBE, and PNAS. He has lead several research projects, including 2 ERC grants. He is an EMBO member and has served on the editorial board of several journals. His current research interests include the origin of multicellular animals, the evolution of complex life forms, and the diversity of eukaryotes.

Research interests

The lab is interested in understanding how multicellular animals emerged from their unicellular ancestors. To this aim, we perform comparative and functional genomic analyses between multicellular animals and their closest unicellular relatives to unravel the nature of the unicellular ancestor that gave rise to animals. We are also currently developing genetic tools in the closest unicellular relatives to Metazoa and trying to address the origin of animal cell differentiation and animal cell types. Finally, we are also interested in unraveling the hidden diversity of eukaryotes using metabarcoding data.

Selected publications

– Denbo S, Aono K, Kai T, Yagasaki R, Ruiz-Trillo I & Hiroshi Suga H 2019, ‘Revision of the Capsaspora genome using read mating information adjusts the view on premetazoan genome‘, Development, Growth & Differentiation, 61:34–42.

– Rafels-Ybern À, Torres AG, Camacho N, Herencia-Ropero A, Roura Frigolé H, Wulff TF, Raboteg M, Bordons A, Grau-Bove X, Ruiz-Trillo I Ribas de Pouplana L 2019, ‘The expansion of Inosine at the wobble position of tRNAs, and its role in the evolution of proteomes‘, Molecular Biology and Evolution, Volume 36, Issue 4, April 2019, Pages 650–662,

– O’Malley M, Leger MM, Wideman JG & Ruiz-Trillo I 2019, ‘Concepts of the last eukaryotic common ancestor’, Nature Ecology & Evolution, 3, 3, 338 – 344.

– Mitsi K, Arroyo AS &  Ruiz-Trillo I 2019, ‘A global metabarcoding analysis expands molecular diversity of Platyhelminthes and reveals novel early-branching clades’, Biology Letters, 15, 9, 20190182.

– Lopez-Escardo D, Grau-Bove X, Guillaumet-Adkins A, Gut M, Sieracki ME & Ruiz-Trillo I 2019, ‘Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals’, Philosophical Transactions Of The Royal Society B-biological Sciences, 374, 1786, 20190088.

– Dudin O, Ondracka A, Grau-Bove X, Haraldsen AAB, Toyoda A, Hiroshi S, Brate J & Ruiz-Trillo I 2019, ‘A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization’, Elife, 8, e49801.

– Ocaña-Pallarès E, Najle SR, Scazzocchio C & Ruiz-Trillo I 2019, ‘Reticulate evolution in eukaryotes: Origin and evolution of the nitrate assimilation pathway‘, PLoS GENETICS 15(2): e1007986