Luis Serrano Pubul

Luis Serrano Pubul

Centre de Regulació Genòmica

Life & Medical Sciences

I did my PhD at the CBM in Madrid on the role of the carboxy-terminal region of tubulin on polymerization and MAP binding. Then I moved to the UK to work on protein folding. In 1993 I moved to the EMBL as a GL and started a new activity related to Protein design. After 6 years I was promoted to Senior Scientist. 2 years later I was appointed head of the Structural & Computational Biology programme. At that time we moved into the field of protein misfolding and amyloidoses diseases. We also started a new area of research on Systems Biology, designing small gene networks, doing computer simulations on them and performing experiments to test the predictions. After 14 years at the EMBL I moved to Spain to lead a programme working on Systems Biology. I was appointed vice-director before finally becoming the CRG director in July 2011. My group is focused on Synthetic Biology, engineering and designing of biological systems using our knowledge on protein design and gene networks.

Research interests

The group of Luis Serrano is interested in the quantitative understanding and in the rational design of Biological Systems. To achieve this goal they combine theoretical and experimental approaches and develop appropriate software. Of particular interest for the group is the combination of protein design and network analysis to understand signal transduction and gene regulation. As a more ambitious project our group is now using Synthetic biology to engineer Mycoplasma pneumoniae as a living pill for human lung therapy.  We also continue developing the software for protein design ModelX and FoldX, to engineer proteins with immunomodulatory activity.  Finally we are exploting the role of codon usage and codon conservation in oncogenic proteins. 

Selected publications

- Hernandez-Alias X, Katanski CD, Zhang W, et al. 2023, 'Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation', Nucleic Acids research. 51(3):e17.

- Montero-Blay A, Blanco JD, Rodriguez-Arce I, et al. 2023, 'Bacterial expression of a designed single-chain IL-10 prevents severe lung inflammation', Molecular Systems Biology, 19, 1, e11037.

- Mazzolini R, Rodríguez-Arce I, Fernández-Barat L, et al.  2023, 'Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms', Nature Biotechnology, 41, 8, 1089-1098.

- Hernandez-Alias X, Benisty H, Radusky LG, Serrano L & Schaefer MH 2023, 'Using protein-per-mRNA differences among human tissues in codon optimization', Genome Biology, 24, 1, 34.

- Benisty H, Hernandez-Alias X, Weber M, et al. 2023, 'Genes enriched in A/T-ending codons are co-regulated and conserved across mammals', Cell Systems, 14, 4, 312-323.

- Weber M, Sogues A, Yus E, Burgos R, Gallo C, Martinez S, Lluch-Senar M & Serrano L 2023, 'Comprehensive quantitative modeling of translation efficiency in a genome-reduced bacterium', Molecular Systems Biology, 19, 10.

- Najle SR, Grau-Bové X, Elek A, et al. 2023, 'Stepwise emergence of the neuronal gene expression program in early animal evolution', Cell, 186, 21, 4676-4693.

- Pascual-Reguant L, Serra-Camprubí Q, Datta D, et al. 2023, 'Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple-negative breast cancer', EMBO Mol Med, 15, 12, e18459.

- Burgos R, Garcia-Ramallo E, Shaw D, Lluch-Senar M & Serrano L 2023, 'Development of a Serum-Free Medium To Aid Large-Scale Production of Mycoplasma-Based Therapies', Microbiology Spectrum, 11, 3, e04859-22.