Thomas Surrey

Thomas Surrey

Centre de Regulació Genòmica

Life & Medical Sciences

Thomas Surrey obtained his PhD in Biochemistry from the University of Tübingen in 1995. After postdoctoral training at Princeton University and the EMBL Laboratory in Heidelberg, he became group leader at EMBL. In 2011, Thomas moved to the CRUK London Research Institute (LRI) to take the position of a senior group leader and later transferred to the newly established Francis Crick Institute in London. In 2019, Thomas relocated to the Centre of Genomic Regulation (CRG), a part of the BIST, to take the position as a CRG senior group leader and ICREA research professor. Thomas is author of 100 research publications, elected EMBO member (2012), recipient of an ERC Advanced Grant (2013) and an ERC Synergy Grant (2021) and of the Hooke medal of the British Society of Cell Biology (2015). He was a Whitman Center Fellow at the Marine Biology Laboratory (MBL) in Woods Hole in 2016 and a Visiting Miller Professor at UC Berkeley in 2018. In 2021, he was selected as an ASCB Fellow.

Research interests

Living cells are internally highly organized, yet also very dynamic. How is dynamic order generated? The cytoskeleton plays a critical role in this process by forming an active filament network that provides a mechanically stable coordinate system for the internal organization of cells. The Surrey lab studies the properties of the microtubule cytoskeleton with a particular interest in its ability to organize itself into different networks in different cell types or at different times of a cell's life cycle. The Surrey lab has pioneered several biochemical in vitro reconstitution approaches in which minimal cytoskeletal subsystems can be generated from purified components. Observing the behaviour of these reconstituted systems by advanced fluorescence microscopy provides insight into the molecular mechanisms underlying cytoskeleton dynamics and function. Our goal is to uncover the design principles governing active biological network organization which is essential for cell function.

Selected publications

- Brito C, Serna M, Guerra P, Llorca O & Surrey T 2024, 'Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation', Science, 383 - 6685 - 870 - 876 - .
- Henkin G, Brito C, Plückthun A & Surrey T 2024, 'Preparation of Polarity-Marked Microtubules Using a Plus-End Capping DARPin', Bio-protocol, 14 - 22 -e5109.
- Lim WM, Chew WX, Esposito Verza A, Pesenti M, Musacchio A & Surrey T 2024, 'Regulation of minimal spindle midzone organization by mitotic kinases' Nat Commun, 15 - 9213.
- Scrofani J, Ruhnow F, Chew WX, Normanno D, Nedelec F, Surrey T & Vernos I 2024, 'Branched microtubule nucleation and dynein transport organize RanGTP asters in Xenopus laevis egg extract', Mol Biol Cell 35 - 12.

Selected research activities

Conferences     
 2-5 April 2024: 'Mechanobiology across scales' conference at University of Cote d'Azur, Nice. Invited seminar.
 7-12 July 2024: 'Molecular Motors' Gordon Conference in Portland, Maine, US, Poster.
 4-6 September 2024, 46º Congreso de la Sociedad Española de Biochímica y Biología Molecular (SEBBM) in A Coruna, Spain. Invited seminar
23-28 September 2024, Workshop 'Exploring cuyoskeletal mechanisms at all scales of life' at Fondation Les Treilles, France. Invited seminar.
 
Invited Seminars
 16 April 2024: University of Geneva, Switzerland
28 June 2024: I IGH in Montpellier, France
12 November 2024, University of California San Diego (UCSD), San Diego, CA, USA
 15 November 2024, University of Southern California (USC), Los Angeles, CA, USA
20 November 2024, University of California Santa Barbara (UCSB), Santa Barbara, CA, USA
PhD theses: 
11 January 2024: PhD defense (supervisor), student: Julia Grawenhoff, Universitat Pompeu Fabra, Barcelona, Spain
29 January 2024: PhD defense (member of jury), student: Anne-Catherine Abel, University of Basel, Switzerland
 16 April 2024: PhD defense (member of jury), student: Julie Miesch, University of Geneva, Switzerland