Thomas Surrey obtained his PhD in Biochemistry from the University of Tübingen in 1995. After postdoctoral training at Princeton University and the EMBL Laboratory in Heidelberg, he became group leader at EMBL. In 2011, Thomas moved to the CRUK London Research Institute (LRI) to take the position of a senior group leader and later transferred to the newly established Francis Crick Institute in London. In 2019, Thomas relocated to the Centre of Genomic Regulation (CRG), a part of the BIST, to take the position as a CRG senior group leader and ICREA research professor. Thomas is author of 93 research publications, elected EMBO member (2012), recipient of an ERC Advanced Grant (2013) and of the Hooke medal of the British Society of Cell Biology (2015). He was a Whitman Center Fellow at the Marine Biology Laboratory (MBL) in Woods Hole in 2016 and a Visiting Miller Professor at UC Berkeley in 2018. In 2021, he was selected as an ASCB Fellow
Living cells are internally highly organized, yet also very dynamic. How is dynamic order generated? The cytoskeleton plays a critical role in this process by forming an active filament network that provides a mechanically stable coordinate system for the internal organization of cells. The Surrey lab studies the properties of the microtubule cytoskeleton with a particular interest in its ability to organize itself into different networks in different cell types or at different times of a cell's life cycle. The Surrey lab has pioneered several biochemical in vitro reconstitution approaches in which minimal cytoskeletal subsystems can be generated from purified components. Observing the behaviour of these reconstituted systems by advanced fluorescence microscopy provides insight into the molecular mechanisms underlying cytoskeleton dynamics and function. Our goal is to uncover the design principles governing active biological network organization which is essential for cell function.
- Henkin G, Chew WX, Nédélec F & Surrey T 2022, 'Cross-linker design determines microtubule network organization by opposing motors', Proc Natl Acad Sci U S A 119, e2206398119.
- LaFrance BJ, Roostalu J, Henkin G, Greber BJ, Zhang R, Normanno D, McCollum CO, Surrey T & Nogales E 2022, 'Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules', Proceedings Of The National Academy Of Sciences Of The United States Of America, 119(2), e2114994119.
- Consolati T, Henkin G, Roostalu J & Surrey T 2022, 'Real-Time Imaging of Single γTuRC-Mediated Microtubule Nucleation Events In Vitro by TIRF Microscopy', Methods Mol Biol, 2430:315-336.