Juan Valcárcel studied biology and chemistry at the Universities of Santiago de Compostela and Autónoma de Madrid. He obtained his PhD in 1990 for work carried out at the Centro de Biología Molecular Severo Ochoa under the supervision of Juan Ortín. He did postdoctoral work in the laboratory of Michael Green at the University of Massachusetts and in 1996 he joined the European Molecular Biology Laboratory in Heidelberg as a group leader. In 2002 his group moved to the Centre de Regulació Genòmica in Barcelona, where he is a senior scientist and ICREA Research Professor. Since the time of his PhD work, his research has focused on how pre-mRNAs are spliced and how this process can be regulated.
The genome provides the instructions to build and maintain the function of a living organism. Strangely, in complex organisms these instructions are not written as continuous messages, but rather as smaller pieces interrupted by meaningless text. This arrangement has the advantage that the pieces can be combined in different ways to generate alternative instructions. We study the molecular machinery that puts messages together and how the production of alternative messages is regulated.
– Baeza-Centurion P, Minana B, Schmiedel JM, Valcarcel J & Lehner B 2019, ‘Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing’, Cell, 176, 3, 549 – +.
– Torres-Mendez A, Bonnal S, Marquez Y, Roth J, Iglesias M, Permanyer J, Almudi I, Ohanlon D, Guitart T, Soller M, Gingras AC, Gebauer F, Rentzsch F, Blencowe BJ, Valcarcel J & Irimia M 2019, ‘A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons’, Nature Ecology & Evolution, 3, 4, 691 – 701.
– Carbonell C, Ulsamer A, Vivori C, Papasaikas P, Bottcher R, Joaquin M, Minana B, Tejedor JR, de Nadal E, Valcarcel J & Posas F 2019, ‘Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK’, Cell Reports, 27, 3, 847 – +.
– Huertas CS, Bonnal S, Soler M, Escuela AM, Valcarcel J & Lechuga LM 2019, ‘Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors’, Analytical Chemistry, 91, 23, 15138 – 15146.
– Hoffmann T & Valcarcel J 2019, ‘Splicing Calls Back’, Cell, 179, 7, 1446 – 1447.
– Keiper S, Papasaikas P, Will CL, Valcárcel J, Girard C & Lührmann R 2019, ‘Smu1 and RED are required for the activation of spliceosomal B complexes assembled on short introns‘, Nature Communications, vol 10, pp 3639