Toni Gabaldón

Toni Gabaldón

Barcelona Supercomputing Center - Centro Nacional de Supercomputación

Life & Medical Sciences

I'm a biochemist and molecular biologist by training. I obtained a PhD in Medical Sciences in 2005 (Radbout University Nijmegen). I was an EMBO postodoctoral fellow at the CIPF (Valencia) before starting my own group at the Bioinformatics and Genomics Department at the CRG (Barcelona, 2008-2019). In 2019 I joined as a Senior group leader the IRB and the BSC (Barcelona). I am ICREA Research professor since 2013 and EMBO member since 2021. I have been awardee of the ERC starting and consolidator grants and received awards such as the Margaret Dayhoff mid-career award (2017), correspondent membership of the Spanish Royal National Academy of Pharmacy, and membership of the Spanish Young Academy. I have co-authored over 250 articles, and founded one spin-off company. I have always used an evolutionary perspective to address different biological questions. I am not only interested in understanding how complex biological systems work, but also how they have come to be as they are.

Research interests

My main research interest is to understand the complex relationships between genome sequences and phenotypes and how these two features evolve within and across species. I generally use large-scale phylogenetics and molecular evolution approaches that allow looking at the evolution of genomes from the perspective of all of their genes, and apply these analyses to a variety of biological questions related to the evolution and function of biological communities, organisms, organelles, pathways, and families of protein-coding and non-coding genes. I have a special interest in understanding processes related to human pathogenesis. Through collaborations with experimental groups, I apply comparative genomics to discover new mechanisms and genes involved in interesting processes, especially those of clinical relevance. Given our exposure to new types and scales of data, my group has had the need to develop novel bioinformatics tools to fill in existing gaps.

Selected publications

- Mixão V, Del Olmo V, Hegedűsová E, Saus E, Pryszcz L, Cillingová A, Nosek J & Gabaldón T 2022, 'Genome analysis of five recently described species of the CUG-Ser clade uncovers Candida theae as a new hybrid lineage with pathogenic potential in the Candida parapsilosis species complex', Dna Research, 29, 2, dsac010.

- Schikora-Tamarit MÀ & Gabaldón T 2022, 'Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens', Biochemical Society Transactions, 30, 50(3), 1259-1268.

- Schikora-Tamarit MÀ & Gabaldón T 2022, 'PerSVade: personalized structural variant detection in any species of interest', Genome Biology, 23, 1, 175.

- Marcet-Houben M, Alvarado M, Ksiezopolska E, Saus E, de Groot PWJ & Gabaldón T 2022, 'Chromosome-level assemblies from diverse clades reveal limited structural and gene content variation in the genome of Candida glabrata', Bmc Biology, 20, 1, 226.

- Naranjo-Ortiz MA, Molina M, Fuentes D, Mixão V, Gabaldón T. 2022, 'Karyon: a computational framework for the diagnosis of hybrids, aneuploids, and other nonstandard architectures in genome assemblies'. Gigascience.  11:giac088.

- Snyder M, Iraola-Guzmán S, Saus E, Gabaldón T 2022, 'Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer'. Cancers (Basel). 14(16):3866.

- Fuentes D, Molina M, Chorostecki U, Capella-Gutiérrez S, Marcet-Houben M & Gabaldón T 2022, 'PhylomeDB V5: an expanding repository for genome-wide catalogues of annotated gene phylogenies', Nucleic Acids Research, 50, D1, D1062 - D1068.

- Willis JR, Saus E, Iraola-Guzmán S, Ksiezopolska E, Cozzuto L, Bejarano LA, Andreu-Somavilla N, Alloza-Trabado M, Blanco A, Puig-Sola A, Broglio E, Carolis C, Ponomarenko J, Hecht J, Gabaldón T. 2022,  'Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors'. NPJ Biofilms Microbiomes. ;8(1):38.