Toni Gabaldón

Toni Gabaldón

Barcelona Supercomputing Center - Centro Nacional de Supercomputación

Life & Medical Sciences

I'm a biochemist and molecular biologist by training (Universities of Valencia and Mainz). After several years working on a molecular biology lab, and attracted by the emerging fields of genomics and bioinformatics, in 2001 I moved to the comparative genomics group of Martijn Huynen in the NCMLS, The Netherlands. In 2005, I obtained a PhD in Medical Sciences (Radbout University Nijmegen), and then moved, thanks to an EMBO fellowship, to the bioinformatics department at CIPF (Valencia). In September 2008 I started my own group in the Bioinformatics and Genomics department at CRG. In 2013 I was awarded an ERC starting grant and an ICREA research professorship. In 2017 I was awarded the ERC consolidator Grant and the Margaret Dayhoff Award. I have always used an evolutionary perspective to address different biological questions. I am not only interested in understanding how complex biological systems work, but also how they have come to be as they are.

Research interests

My main research interest is to understand the complex relationships between genome sequences and phenotypes and how these two features evolve within and across species. I generally use large-scale phylogenetics and molecular evolution approaches that allow looking at the evolution of genomes from the perspective of all of their genes, and apply these analyses to a variety of biological questions related to the evolution and function of biological communities, organisms, organelles, pathways, and families of protein-coding and non-coding genes. I have a special interest in understanding processes related to human pathogenesis. Through collaborations with experimental groups, I apply comparative genomics to discover new mechanisms and genes involved in interesting processes, especially those of clinical relevance. Given our exposure to new types and scales of data, my group has had the need to develop novel bioinformatics tools to fill in existing gaps.

Selected publications

- Julca, Irene; Marcet-Houben, Marina; Cruz, Fernando; Vargas-Chavez, Carlos; Johnston, John Spencer; Gomez-Garrido, Jessica; Frias, Leonor; Corvelo, Andre; Loska, Damian; Camara, Francisco; Gut, Marta; Alioto, Tyler; Latorre, Amparo; Gabaldon, Toni 2020, 'Phylogenomics Identifies an Ancestral Burst of Gene Duplications Predating the Diversification of Aphidomorpha', Molecular Biology And Evolution, 37, 3, 730 - 756.

- Iraola-Guzman, Susana; Brunet-Vega, Anna; Pegueroles, Cinta; Saus, Ester; Hovhannisyan, Hrant; Casalots, Alex; Pericay, Carles; Gabaldon, Toni 2020, 'Target Enrichment Enables the Discovery of lncRNAs with Somatic Mutations or Altered Expression in Paraffin-Embedded Colorectal Cancer Samples', Cancers, 12, 10, 2844.

- Willis, Jesse R.; Gabaldon, Toni 2020, 'The Human Oral Microbiome in Health and Disease: From Sequences to Ecosystems', Microorganisms, 8, 2, 308.

- Mixao, Veronica; Gabaldon, Toni 2020, 'Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans.', Bmc Biology, 18, 1, 48 - 48.

- Chorostecki, Uciel; Molina, Manuel; Pryszcz, Leszek P.; Gabaldon, Toni 2020, 'MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life', Nucleic Acids Research, 48, W1, W553 - W557.

- Pittis, Alexandros A.; Goh, Valerie; Cebrian-Serrano, Alberto; Wettmarshausen, Jennifer; Perocchi, Fabiana; Gabaldon, Toni 2020, 'Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter', Nature Communications, 11, 1, 4031.

- Fernandez, Rosa; Gabaldon, Toni 2020, 'Gene gain and loss across the metazoan tree of life', Nature Ecology & Evolution, 4, pp. 524–533.