Toni Gabaldón

Toni Gabaldón

Institut de Recerca Biomèdica de Barcelona & Barcelona Supercomputing Center - Centro Nacional de Supercomputación

Life & Medical Sciences

I'm a biochemist and molecular biologist by training (Universities of Valencia and Mainz). After several years working on a molecular biology lab, and attracted by the emerging fields of genomics and bioinformatics, in 2001 I moved to the comparative genomics group of Martijn Huynen in the NCMLS, The Netherlands. In 2005, I obtained a PhD in Medical Sciences (Radbout University Nijmegen), and then moved, thanks to an EMBO fellowship, to the bioinformatics department at CIPF (Valencia). In September 2008 I started my own group in the Bioinformatics and Genomics department at CRG. In 2013 I was awarded an ERC starting grant and an ICREA research professorship. In 2017 I was awarded the ERC consolidator Grant and the Margaret Dayhoff Award. I have always used an evolutionary perspective to address different biological questions. I am not only interested in understanding how complex biological systems work, but also how they have come to be as they are.

Research interests

My main research interest is to understand the complex relationships between genome sequences and phenotypes and how these two features evolve within and across species. I generally use large-scale phylogenetics and molecular evolution approaches that allow looking at the evolution of genomes from the perspective of all of their genes, and apply these analyses to a variety of biological questions related to the evolution and function of biological communities, organisms, organelles, pathways, and families of protein-coding and non-coding genes. I have a special interest in understanding processes related to human pathogenesis. Through collaborations with experimental groups, I apply comparative genomics to discover new mechanisms and genes involved in interesting processes, especially those of clinical relevance. Given our exposure to new types and scales of data, my group has had the need to develop novel bioinformatics tools to fill in existing gaps.

Selected publications

– Saus E, Iraola-Guzman S, Willis JR, Brunet-Vega A & Gabaldon T 2019, ‘Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential’, Molecular Aspects Of Medicine, 69, 93 – 106.

– Naranjo-Ortiz MA & Gabaldon T 2019, ‘Fungal evolution: diversity, taxonomy and phylogeny of the Fungi’, Biological Reviews, 94, 6, 2101 – 2137.

Gabaldon T et al. 2019, ‘Recent trends in molecular diagnostics of yeast infections: from PCR to NGS’, Fems Microbiology Reviews, 43, 5, 517 – 547.

– Zhao et al. (including; Gabaldon T) 2019, ‘A comprehensive genome variation map of melon identifies multiple domestication events and loci influencing agronomic traits’, Nature Genetics, 51, 11, 1607 – +.

Gabaldon T & Fairhead C 2019, ‘Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal’, Current Genetics, 65, 1, 93 – 98.

– Marcet-Houben M & Gabaldon T 2019, ‘Evolutionary and functional patterns of shared gene neighbourhood in fungi’, Nature Microbiology, 4, 12, 2383 – 2392.

– Pegueroles C, Iraola-Guzman S, Chorostecki U, Ksiezopolska E, Saus Ester & Gabaldon T 2019, ‘Transcriptomic analyses reveal groups of co-expressed, syntenic lncRNAs in four species of the genus Caenorhabditis’, Rna Biology, 16, 3, 320 – 329.

– Naranjo-Ortiz MA & Gabaldon T 2019, ‘Fungal evolution: major ecological adaptations and evolutionary transitions.’, Biological Reviews Of The Cambridge Philosophical Society, 94, 4, 1443 – 1476.

– Gonzalez-Torres P, Rodriguez-Mateos F, Anton J & Gabaldon T 2019, ‘Impact of Homologous Recombination on the Evolution of Prokaryotic Core Genomes’, Mbio, 10, 1, e02494-18.

– Mariotti M, Salinas G, Gabaldon T & Gladyshev V 2019, ‘Utilization of selenocysteine in early-branching fungal phyla’, Nature Microbiology, 4, 5, 759 – 765.