Toni Gabaldón Estevan

Toni Gabaldón Estevan

Barcelona Supercomputing Center - Centro Nacional de Supercomputación

Life & Medical Sciences

I'm a biochemist and molecular biologist by training. I obtained a PhD in Medical Sciences in 2005 (Radbout University Nijmegen). I was an EMBO postodoctoral fellow at the CIPF (Valencia) before starting my own group at the Bioinformatics and Genomics Department at the CRG (Barcelona, 2008-2019). In 2019 I joined as a Senior group leader the IRB and the BSC (Barcelona). I am ICREA Research professor since 2013 and EMBO member since 2021. I have been awardee of the ERC starting and consolidator grants and received awards such as the Margaret Dayhoff mid-career award (2017), correspondent membership of the Spanish Royal National Academy of Pharmacy, and membership of the Spanish Young Academy. I have co-authored over 250 articles, and founded one spin-off company. I have always used an evolutionary perspective to address different biological questions. I am not only interested in understanding how complex biological systems work, but also how they have come to be as they are.

Research interests

My main research interest is to understand the complex relationships between genome sequences and phenotypes and how these two features evolve within and across species. I generally use large-scale phylogenetics and molecular evolution approaches that allow looking at the evolution of genomes from the perspective of all of their genes, and apply these analyses to a variety of biological questions related to the evolution and function of biological communities, organisms, organelles, pathways, and families of protein-coding and non-coding genes. I have a special interest in understanding processes related to human pathogenesis. Through collaborations with experimental groups, I apply comparative genomics to discover new mechanisms and genes involved in interesting processes, especially those of clinical relevance. Given our exposure to new types and scales of data, my group has had the need to develop novel bioinformatics tools to fill in existing gaps.

Selected publications

- Marlétaz F, de la Calle-Mustienes E, Acemel RD, Paliou C, Naranjo S, Martínez-García PM, Cases I, Sleight VA, Hirschberger C, Marcet-Houben M, Navon D, Andrescavage A, Skvortsova K, Duckett PE, González-Rajal Á, Bogdanovic O, Gibcus JH, Yang L, Gallardo-Fuentes L, Sospedra I, Lopez-Rios J, Darbellay F, Visel A, Dekker J, Shubin N, Gabaldón T, Nakamura T, Tena JJ, Lupiáñez DG, Rokhsar DS & Gómez-Skarmeta JL 2023. 'The little skate genome and the evolutionary emergence of wing-like fins'. Nature. 2023 Apr;616(7957):495-503. 
- Del Olmo V, Mixão V, Fotedar R, Saus E, Al Malki A, Księżopolska E, Nunez-Rodriguez JC, Boekhout T & Gabaldón T 2023, 'Origin of fungal hybrids with pathogenic potential from warm seawater environments'. Nat Commun. 14(1):6919. 

- Gabaldon T 2023, 'Nothing makes sense in drug resistance except in the light of evolution', Current Opinion In Microbiology, 75, 102350.

- Khannous-Lleiffe O, Willis JR, Saus E, Moreno V, Castellvi-Bel S & Gabaldon T 2023, 'Microbiome Profiling from Fecal Immunochemical Test Reveals Microbial Signatures with Potential for Colorectal Cancer Screening', Cancers, 15, 1, 120.

- Marcet-Houben M, Collado-Cala I, Fuentes-Palacios D, et al. 2023, 'EvolClustDB: Exploring Eukaryotic Gene Clusters with Evolutionarily Conserved Genomic Neighbourhoods', Journal Of Molecular Biology, 435, 14, 168013.

- Julca I, Vargas P & Gabaldón T 2023, 'Phylogenomics of the Olea europaea complex using 15 whole genomes supports recurrent genetic admixture together with differentiation into seven subspecies', Bmc Biology, 21, 1, 85.

- Mixão V, Nunez-Rodriguez JC, Del Olmo V, et al. 2023, 'Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens', Bmc Biology, 21, 1, 105.