Javier Martínez-Picado

Javier Martínez-Picado

Institut de Recerca de la Sida - IrsiCaixa

Life & Medical Sciences

Javier Martinez-Picado is ICREA Research Professor at the IrsiCaixa AIDS Research Institute in Barcelona. He is also an associate professor at the University of Vic, and an elected member of the Royal Academy of Science and Arts of Barcelona. He obtained his PhD in Microbiology from the University of Barcelona, where he also lectured as an associate professor. In 1996, he joined Massachusetts General Hospital as a research fellow at Harvard Medical School, where he focused on HIV/AIDS research. In 2000 he obtained the position of biomedical researcher at the Spanish Health Department appointed to the Hospital Germans Trias de Badalona. In 2006 he obtained his current ICREA position. Dr. Martinez-Picado serves on different government, academic and industry advisory boards. He has given numerous invited lectures in multiple countries, and has published more than 240 articles on virology and immunology topics, mainly related to the pathogenesis of HIV, in international journals.

Research interests

His research is focused on characterizing the immuno-virological mechanisms of viral pathogenesis in human diseases, including HIV-1, Ebola virus, arenaviruses and, more recently, SARS-CoV-2. His group’s translational program has the ultimate goal of investigating potential new viral therapeutic strategies, especially in the field of HIV/AIDS, through basic and applied research. They work closely with other national and international biomedical institutes, focusing on three priority research topics: understanding viral persistence to tackle HIV cure strategies, viral pathogenesis mediated by myeloid cells, and extreme phenotypes of virus disease progression. As a result of the COVID-19 pandemic, they have expanded their research to the pathogenesis of SARS-CoV-2, implementing organoid models to assess viral infection and inflammatory responses.

Selected publications

- McLaren PJ, et al 2023, 'Africa-specific human genetic variation near CHD1L associates with HIV-1 load', Nature 620(7976):1025-30.
- García-González L, et al 2023, 'Understanding the neurological implications of acute and long COVID using brain organoids', Dis Models Mech 16(7):dmm050049.
- Morón-López S, et al 2023, 'Comparison of RT-qPCR and RT-ddPCR for Detection of Genomic and Subgenomic SARS-CoV-2 RNA', Microbiol Spectr 11(2):e0415922.
- Campos-Gonzalez G, et al 2023, 'Opportunities for CAR-T Cell Immunotherapy in HIV Cure', Viruses 15(3):789.
- Paton B, et al 2023, 'Fucosylated N-glycans as early biomarkers of COVID-19 severity', Front Immunol 14:1204661.
- Rosado-Sánchez I, et al 2023, 'Caecum OX40DCD4 T-cell subset associates with mucosal damage and key markers of disease in treated HIV-infection', J Microbiol Immunol Infect 56(6):1129-38.