Cancer is a genetic disease in which accumulated mutations of driver genes induce a functional reorganization of the cell by reprogramming cellular pathways. Current approaches identify cancer pathways as those most internally perturbed by gene expression changes. However, driver genes characteristically perform hub roles between pathways. We show that cancer pathways should be identified by changes in their pathway–pathway relationships.
Barcelona Supercomputing Center - Centro Nacional de Supercomputación (BSC-CNS)
– Windels SFL, Malod-Dognin N & Pržulj N 2022, ‘Identifying cellular cancer mechanisms through pathway-driven data integration’, Bioinformatics, Volume 38, Issue 18, Pages 4344–4351.